Continuous calf muscle twitching can be caused by serious conditions, such as Lou Gehrig's disease and muscular dystrophy, according to Healthline. While mild twitching is not usually considered dangerous, it is important for individuals with chronic calf twitching to consult with a physician to ensure a proper diagnosis.
Exercise, stress, nutritional deficiencies, smoking, lack of sleep, use of caffeine and reactions to certain drugs can cause calf muscles to twitch, adds MedlinePlus. Symptoms normally dissipate within a few days.
Continuous muscle twitching can also be attributed to nerve damage. Additional symptoms of a nerve condition can include loss of sensation in the muscle and muscle weakness.
Tests to determine the underlying causes of continual twitching include computed tomography scans, nerve conduction studies, spinal scans and brain scans, according to MedlinePlus. Doctors may also administer blood tests to check for electrolyte and thyroid imbalances.