Gentle Giants Rescue, Big Dogs Huge Paws and the Southern States Mastiff Rescue are three of the largest mastiff rescue organizations in the country, and they all offer mastiff puppies for adoption. Large dog rescue organizations, rescuing mastiff puppies and adults of all ages, are located throughout the United States.
Mastiffs and other large dog breeds are some of the most difficult dog breeds for adoptive and rescue organizations to handle because of their size. As a result, organizations such as the ASPCA or other large-scale rescue organizations often turn to specialized units for placement of mastiffs and other large dog breeds. When looking for mastiff puppies, it is important to find an organization that specializes in caring for large dogs and responsibly placing them in adoptive homes.