Wild cottontail rabbits usually mature at around 2 to 3 pounds. Some domestic breeds of rabbit mature at 12 to 14 pounds or even larger. For example, the Flemish Giant usually reaches around 14 pounds, but occasionally can grow as large as 22 pounds.
The large breeds of domestic rabbit were developed to provide meat, with the larger size meaning that more meat per rabbit is produced.
Most non-meat domestic breeds of rabbit are about the same size as wild rabbits, maturing at 2 to 4 pounds. A few breeds, such as the Netherlands dwarf, are slightly smaller. The rare Columbia Basin pygmy rabbit matures at less than 1 pound.