Although there are few statistics kept on mixed breed dogs, the average litter size for both Chihuahuas and Miniature Pincers is two to four puppies. This suggests a Chihuahua and Miniature Pincer pairing is most likely to result in two to four puppies per litter.
In general, large dogs produce a larger number of puppies per litter. Large breeds can average 10 to 12 puppies. Small breeds usually have small litters of two to four puppies. Besides breed type, litter size is also affected by other factors, such as the age of the mother and her general health and nutrition.