Predators of rabbits include larger mammals, such as coyotes, foxes, raccoons and opossums; predatory birds, such as owls, hawks and snakes; and domesticated animals, such as cats and dogs. Rabbits are vulnerable to predation from many animals, but their risk of predation varies depending on their environments. Rabbits living in urban areas fall prey to larger domesticated animals, such as cats and dogs, while those living in the wild fall victim to predatory birds and larger mammals.
Wild rabbits see threats from more species than urban rabbits, including several species of owls and larger birds. One of their main avian predators is the Great Horned Owl. Great Horned Owls, like rabbits, classify as nocturnal. They feed and hunt during the nighttime, making swift and silent attacks on rabbits. Rabbits and hares, larger close cousins of rabbits that live in the Western United States, comprise nearly 75 percent of the owls' diet.
While wild rabbits fear raptors and large mammals, urban rabbits face threats from household pets and even humans. Sometimes people accidentally disturb and damage rabbit nests performing routine activities like mowing the lawn. As with other animals, disease and illness pose threats to some rabbit populations; these animals are susceptible to tularemia, a disease that transmits to humans.