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What is a Scatchard plot?

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A Scatchard Plot is a method for analyzing the affinity constant of a ligand and its receptor protein. It is a visual representation of the Scatchard equation.

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The Scatchard plot allows chemists to understand the composition of micro-labeled drugs and the manner in which they bind to homogenous receptor drugs. On the Scatchard plot, x values represent the amount of micro-labeled drugs that bind to the receptor. The y values represent this x amount divided by the amount of micro-labeled drugs free in the solution. The curve of the plot is measured by the equation -1/K(d), with K(d) representing the separation value for a ligand. The plot is named after its inventor, American chemist and MIT professor George Scatchard.

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