The best way to kill bed bugs is to use an integrated pest management approach. First, collect all the infected items, bag them and launder at 122 degrees Fahrenheit or higher. Thoroughly steam all the infected areas in the house, paying most attention to corners and seams, then vacuum the house, and spray the infected areas with insecticides. Remove damaged items that are impossible to disinfect, such as mattresses. Apply silica gel to the walls, floor, mattresses, couches and chairs.
Before starting to get rid of bugs, find all the locations where they live. Examine mattresses, beds, nightstands and dressers for bed bugs and their eggs. Pay most attention to cracks, crevices, seams and corners. Check all chairs and sofas. Bugs usually live in the seams, tufts, skirts and crevices under cushions. Other common places where bed bugs live are edges of wall-to-wall carpeting, cracks in wood molding and ceiling-wall junctures
After eradicating all the bed bugs, prevent them from entering again. Don't bring secondhand beds, bedding and furniture into the house. When traveling, check beds and headboards for signs of bed bugs. Make sure that your new furniture hasn't been stored in bug-infested warehouses and hasn't been shipped in infected containers and transport.