Imidan, Sevin, New Spectracide, Methoxychlor and Thiodan are insecticides that can be used to control the potato beetle. Bacillus thruingiensis var. tenebrionis (Bt) is effective against potato beetle larvae. Without intervention, the potato beetle can reduce yield and kill plants.
The potato beetle rapidly develops resistance to insecticides, especially when an insecticide is used repeatedly. Rotation of insecticides delays or prevents resistance to insecticides that the overuse of a single product can cause. The rotation should be between different classes of insecticide chemicals for this to work properly. Hand picking the adult beetles is another effective method of pest control.