A table saw fit with a blade with finely spaced teeth, a laser or water jet cutter, a twist drill with bits for acrylic, and water-resistant sand paper for wet-sanding are some suitable tools for working with Plexiglas. Thin sheets can be cut with a scribing knife.
Plexiglas is one brand of transparent acrylic plastic. It is lighter, stronger and more insulating than glass.
Some important tips for working with acrylic are to avoid friction heat and to take care to get as straight and smooth cuts as possible, as sanding it is time-consuming. It is also not as hard as glass, and the surface can get scratched, so its protective film should be kept on while working with the material.