The schedule for cleaning a Mr. Coffee coffeemaker largely depends on the hardness of the water used for brewing. Mr.Coffee instruction manuals, which are available on the company website, suggest cleaning after 80 cycles using soft water and 40 cycles using hard water.
A Mr. Coffee coffeemaker is cleaned by running vinegar, instead of water, through the brewing cycle. After most of the vinegar has passed through the machine, Mr. Coffee is turned off and allowed to stand for around 30 minutes. The vinegar is then poured back into the reservoir, and a full cycle is run. The vinegar is disposed of, and a full cycle of plain water removes any residue. The decanter and lid are easily cleaned on the top-rack of the dishwasher.