DoItYourself.com recommends using nail polish remover to remove caulk from the hands. The process involves vigorously rubbing the area with soap and water, and then peeling away the large pieces of caulk before applying nail polish remover to remove any traces of caulk that are left behind.
The first step in removing caulk from the hands is rubbing the hands vigorously with soap and water. Three or four washings are recommended before proceeding on to the next step, which is applying the nail polish remover. It is important to apply the nail polish remover in a well-ventilated area and choose a remover that uses acetone as an active ingredient. Soaking a cotton ball in the nail polish remover and rubbing it against the caulk until it begins to loosen is a good strategy. The last step is peeling the loosened caulk off of the skin before washing the hands thoroughly with soap and water to remove any acetone that is left behind.
FamilyHandyman.com recommends a different method of caulk removal. Wiping caulk off of the skin with a cloth dampened with paint thinner is effective. Another solution is to simply wear thick gloves when applying caulk to avoid getting it on the hands altogether.