To eliminate skunk odor in a house, ventilate the rooms by opening windows and keeping fans on high to circulate air, and use an odor-removing treatment. Some treatments include baking soda and peroxide, enzyme-based solutions and vinegar treatments.
Use enzyme-based solutions on hard surfaces, carpets, clothing and upholstery. Wear rubber gloves, and wipe up the skunk spray before applying the solution. Using a clean rag, completely saturate the affected areas with the undiluted solution, and allow it to air dry. If the odor is not gone, repeat the application until it is no longer noticeable.
Use baking soda and peroxide on the same surfaces as well as people and pets, avoiding eyes, mouths and open sores. Combine the two ingredients with a small amount of liquid dish soap in a large container so the foam does not spill over. Saturate an old rag with the mixture, and scrub it into the affected area. Rinse the area with water, and allow it to dry. Repeat until the smell is gone.
Vinegar is best for delicate fabrics that cannot be cleaned with hot water. Mix one part distilled white vinegar with four parts water in a large container. Allow the fabric to soak in the container for up to three hours, and then wash the fabric in a delicate cycle with detergent and 1/2 cup of baking soda. Let the fabric hang dry. Place open bowls of distilled white vinegar in the corner of the affected rooms, or spray it onto the curtains or upholstery.