To declutter a home office, a rule of "everything has a place" needs to be enforced. If the item is valuable enough to keep, it must have a place to permanently reside. After someone uses the item, he must return it to its designated place.
Office inhabitants should keep work desks clear of loose papers, pens, pencils, paperclips and other supplies. Creating folders organized in bins eliminates loose papers. Small storage bins for small office supplies create a place for pens, pencils and paperclips.
Using a label maker helps ensure that each bin is properly designated, so even those unfamiliar with the area know where to return items.