Some cleaning solutions for mattresses include vacuuming, spot cleaning, deodorizing and airing out. To prevent further mattress stains and messes, use a mattress cover. To spot clean, use natural enzyme cleaners or a mixture of hydrogen peroxide, liquid soap and baking soda. Baking soda is also useful for deodorizing.
Prior to spot cleaning and deodorizing the mattress, use a vacuum to get rid of surface dust. The type of spot cleaner solution depends on the type of stain. Spray the cleaner directly on the stain, and dry with a clean towel. To deodorize, spread a layer of baking soda over the mattress, and leave it on for a few hours. Leave out the mattress in the sunlight and fresh air to get rid of bacteria naturally.