Because having luggage cleaned professionally can be expensive, cleaning your luggage at home can save you quite a bit of money. If you are using nylon luggage, your task is fairly simple.
Clean luggage with mild soap
Because most nylon luggage is coated with Teflon, it is easy to clean. Dip a soft nylon brush in a solution of warm water and gentle soap. You can also use upholstery cleaner that is designed for nylon fabrics or nylon-wood blends. Scrub the entire piece of luggage rather than just treating spots. Do not get any leather trim wet.
Clean the wheels
Wipe off any loose dirt or dried-on soil from the wheels. Wipe them down with the same water and soap solution you used for the nylon panels of the luggage. Luggage wheels do not need lubrication.
Clean the hardware
Wipe down the hardware on your nylon luggage with the same soap and water solution, including the handles, zippers and protective bumpers. Do not use any oil-based cleaner on these parts of the luggage because it stains the nylon surface of the bag.
Clean the inside of the luggage
Sprinkle dry baking soda inside the bag and allow it to sit for an hour or so before you vacuum it out. If you have stayed in a location that had bed bugs, spray the bag with rubbing alcohol, then vacuum the bag thoroughly. Let the bag air dry in the shade.