Cleaning a microfiber purse requires an understanding of what type of microfiber it is. There are four main types: W, S, S-W and X. Depending on the type, cleaning may require a water-based solvent, alcohol-based solvent or no solvent at all.
The process of cleaning a microfiber purse is no different than cleaning any other microfiber item. The inside tag should say from what type of microfiber the purse is made. The "W" type means that water may be used on the purse. If it is an "S," a solvent-based cleaner is required. "S-W" means that the microfiber accepts both water- and solvent-based treatments. "X" means that no solvent should be used and the cleaner must rely on a vacuum, which may be quite trying with a purse.
Depending on the value of the purse, it may be best to consult with the manufacturer of the bag or possibly even with a dry cleaner if there is any doubt as to what type of microfiber the purse is primarily. Also, sometimes microfiber becomes crunchy after it has been cleaned. This is a common issue that occurs. It is possibly fixed by brushing the microfiber with a stiff brush or toothbrush.