Homemade plexiglass cleaner can be made using a mild solution of warm water and dish detergent. For those interested in purchasing a commercial cleaner, Novus #1 and Brillianize are two recommended cleaners for plexiglass.
When cleaning plexiglass, it is important not to use any kind of chemical cleaner that contains ammonia since it will harm the plexiglass acrylic. Cleaners such as Windex or 409 should be avoided at all costs. A person should also be careful not to use their bare hand or a dry cloth to clean plexiglass. Any dust or dirt should be blown off, and then a slightly damp, soft cloth can be used with the homemade plexiglass cleaner.
Children are also problematic when it comes to plexiglass and need to be taught that hard toys will damage the plexiglass surface. Deep scratches are difficult to remove from plexiglass, so it's best to keep the plexiglass item in an area where it won't have contact with sharp objects.