There are multiple sites that allow users to play Pinochle both against computerized and human opponents. Sites like Mystic Island and PlayOK offer traditional, multiplayer Pinochle 24 hours a day.
Many major game sites that cover classic board and card games have Pinochle rooms for players. Pogo.com, for example, is a well-known gaming site that features Pinochle, including additional features like being able to customize the look of the table and a tutorial for players new to the game, teaching the rules and basic strategies involved.
Seasoned players may prefer to play on other sites which have fewer additional features but are simpler in terms of presentation and navigation. Because Pinochle is inherently designed for group play, most sites with Pinochle available to play include the ability to chat with other people, giving players the chance to communicate during the game, swap strategies and advice, and also make new friends.