Scientific research into the long-term benefits of brain games is mixed. While it frequently highlights the tendency of participants to make limited improvements in some cognitive functions over time, there is no evidence that such games improve brain cell function, notes Scientific American.
There is some reason to believe that following certain educational practices at a young age enhances brain functioning for later life, explains Scientific American. In adulthood, however, there may be a ceiling beyond which brain games provide further improvements.
In advanced age, those suffering from diseases such as Alzheimer's may be able to use cognitive training programs to improve upon particular tasks such as activities of daily living, although in the long-term, any benefits are likely to degrade in the event of disease progression, according to Scientific American.