As long as the game is not rigged, keno is a game of pure luck, therefore there is no strategy to picking numbers that improve the odds of winning. The best a keno player can do to improve the odds for himself is to find the best possible pay table.
The "house edge", or the probability of the house winning, will vary depending on the pay table. A 2001 survey of every live keno casino game conducted by the Wizard of Odds website found that keno returns ranged from 65 percent to 80 percent, making it one of the most disadvantageous games for the player in the city. A similar survey of video keno in San Diego conducted in 2008 found that the returns were significantly better than in live games.