A negative chronotropic effect is an action to the heart that causes the organ to beat slower than before. This is often achieved by increasing vagal or parasympathetic stimulation or decreasing sympathetic stimulation on the heart.
A negative chronotropic effect describes a mechanism causing the heart rate to slow down. Chronotropic effects are often referred to when speaking about drugs that affect the heart rate. This is done by affecting the nerves that control the rhythm of the heart. A negative chronotropic effect is one that causes the heart rate to slow down, while a positive chronotropic effect is one that causes the heart rate to speed up.
Beta-blockers, such as Propranolol, cause a negative chronotropic effect on the heart, and are used as medication for various forms of heart disease. Digoxin is another drug that causes the heart rate to slow down. This form of heart rate control can help healthcare professionals alleviate problems caused by an elevated heart rate. By slowing down the heart rate, the heart has more time to fill with blood before pumping, making the process more efficient. At the same time, it also gives the heart more time to relax, allowing it more time to take up oxygen and rest.