The number of five dollar bill misprints is unknown. Misprints happen on occasion at the Bureau of Engraving. Common misprints include misplaced Treasury seals, inverted serial numbers, pages that get folded during printing and an inverted overprint of the serial number and Treasury seal.
Other types of U.S. bill misprints are misalignments. U.S. bills are printed three-across in sheets of 36. A misalignment occurs when the paper fails to align with a printing press plate by the sheet being moved up or to the side of the printing plate with the result that one bill is missing a section or appears to be cut off. When this occurs, the printing on the bill may be moved to the side, up or down from its normal position.