The chords of "Mr. Brightside" are C, C/B, F, A minor and G. To play the song, place a capo on the first fret, and tune the guitar to standard tuning.
The short introduction of the song starts on C before it transitions into C/B and concludes on F. The first stanza of both the first and second verses is played in the order of C to C/B to F and back to C. The next stanza follows the same structure. The third and fourth stanzas of the first and second verses omit the first C chord and instead play C/B to F to C.
For the pre-chorus, each three-line stanza is played with A minor being used on the first line, G being used on the second line, and F being used on the third line.
The chorus starts on C and transitions from F to A minor on the second line, G to C on the third line, and F to A minor again on the fourth line. The fifth line transitions from G to C, while the sixth line transitions from F to A minor. The seventh line is played in the order of G to C to F, and the last line is played in the order of A minor to G.
The instrumental section that follows the second chorus as well as the conclusion of the song are both played in the order of C to F to A minor to G.