The significance of the Proclamation of 1763 was that the colonial settlers in America were protected from Indian attacks and the Indians land was protected from colonial encroachment. The proclamation was initially created to be used temporarily but it ended up lasting until the beginning of the American Revolution.
With the proclamation, the British government was the only entity that was allowed to trade or buy land from the Indians. The colonial governments and citizens of the new world were not allowed to make any type of agreement with the Indians for land or for other supplies. At the Appalachian Divide, the land to the west of it, was given to the Indians by the British government.