There are many major river systems that did not host the world's first civilizations. These include, ordered by length, the Amazon, the Mississippi, the Ob, the Yenisei-Angara, the Congo, the Amur, the Parana, the Lena, the Mackenzie, the Volga, the Zambezi, the Orninoco and the Yukon.
While many of the world's first civilizations arose around rivers, most river systems did not host these civilizations. The river systems that hosted the first civilizations were the Euphrates, the Tigris, the Nile, the Indus and the Yellow or Hueng Hi. While later civilizations may have arisen independently around other rivers, scholars generally agree that these five rivers were the earliest centers of agriculture and city-building.