Rome was built around the seven hills, which provided a great strategic advantage during war and made the defense of Rome a lot easier. The land was fertile and perfect for agriculture due to accessibility of fresh water from the river Tiber.
The Tiber provided an inland waterway for trade and commerce to thrive. Rome was located away from the sea and safe from pirate attacks. The proximity of Rome to the Mediterranean Sea gave it a huge advantage in terms of transportation of goods and people. The warm climate gave Rome an added advantage. Civilization is always likely to flourish with such natural advantages.