The Karankawa Indians traded conch shells in exchange for red ocher, skins, deer hair for tassels and flint. They traded with other inland tribes, particularly the Tonkawa and Caddo.
Little is known about the way Karankawa Indians traded with other tribes in their proximity. They lived along the coastal bend of Texas, typically along the lagoons and bays. Some theories suggest that they traded with the Coahuiltecans at the west end of their territory and even shared camps with them. The Karankawa Indians used canoes to wade across the bays and lagoons and probably used them for trade purposes as well.