The first British colony created in what would become the United States was on Roanoke Island in Virginia, led by Sir John Rolfe, in 1585. A year later, the colonists were driven out by Native Americans.
Rolfe made a second attempt at the same site in 1587 with a group of 115 settlers, including women and children. It vanished after only three years, disappearing without a trace except for the word "Croatan" carved on a tree.
The large and prosperous Lumbee Tribe of North Carolina claim to be the descendants of some of these settlers on the basis of oral history and their mixed racial heritage. However, this theory has been mostly debunked by scientists and historians, and the true fate of the settlers remains a mystery.