What Are the Worst Side Effects of Amitriptyline?

The most serious side effects of amitriptyline requiring immediate medical attention include hallucinations, seizures, uncontrollable shaking or spasms, jaundice and chest pain. Unusual bleeding or bruising, swelling of the face and throat, dizziness, slow or difficult speech, and a skin rash or hives are other serious side effects of the medication that require medical attention, according to Everyday Heath.

Common side effects of amitriptyline not considered dangerous unless they are persistent or severe include

headaches, nightmares, gastrointestinal upset, changes in weight or appetite and blurred vision, as listed by Everyday Health. Other side effects include confusion, changes in sex drive or ability, unsteadiness, drowsiness, difficulty urinating, and pain, burning or tingling in the hands or feet, according to MedlinePlus.

Amitriptyline and other antidepressants pose a risk of suicidal behavior in children, teenagers and young adults up to the age of 24, as reported by MedlinePlus. Signs of suicidal behavior include thinking about or planning to harm oneself or commit suicide, new or worsening depression, aggressiveness, panic attacks, and difficulty falling or staying asleep. Certain factors may increase the possibility of side effects, so it is important for patients to discuss other medications, medical conditions and medical concerns with the prescribing physician.