The worst type of liver disease is cirrhosis of the liver, which replaces healthy cells with scar tissue. Cirrhosis has different causes such as hepatitis types B, C and D; prolonged heavy drinking of alcohol; fatty liver disease and from inheritance, according to Better Health Channel.
The scar tissue affects the normal flow of blood through the liver by damaging the structure of the liver. Cirrhosis causes the liver to harden and form lumps, impairing its normal functions. Symptoms of cirrhosis include loss of appetite, nausea, tiredness, dark colored urine and hair loss. Other symptoms include cognitive problems and fluid retention in the legs and abdomen, claims Better Health Channel.