When caused by vitamin B-12 or folate deficiency, macrocytosis treatment may include diet modification, dietary supplements and injections, explains Mayo Clinic. Macrocytosis resulting from severe anemia may require a blood transfusion.
Macrocytosis describes abnormally large red blood cells, which may lead to oxygen deficiency throughout the body over time. The condition is not a specific disease, and may cause fatigue, poor concentration, dizziness and shortness of breath or exhibit no symptoms at all, according to Healthgrades. Macrocytosis is usually detected on routine blood tests, explains Mayo Clinic, In some instances, macrocytosis may require the removal of a bone marrow sample to determine its origin.