One of the more common ways to treat hives in adults is with over-the-counter oral antihistamines, according to Mayo Clinic. For more severe episodes of hives, a doctor can prescribe a corticosteroid, such as prednisone.
Omalizumab is another corticosteroid medicine commonly prescribed to treat hives, according to WebMD. Chronic hives may be treated with a combination of both antihistamines and corticosteroids. If the condition becomes more severe or does not respond to treatment, injections of epinephrine are used. A doctor could also prescribe medicines to calm a person's immune system in more severe cases, states Mayo Clinic. At home, a person could try applying a cool compress to control itching or take a cool bath that contains a small amount of baking soda or oatmeal, either uncooked or colloidal.