Ways to remove foot calluses include taking medications to reduce infection or remove calluses, cutting away the thickened skin with a scalpel, and wearing custom-made shoe inserts, according to Mayo Clinic. In certain cases, surgery may be necessary to align the bone that causes friction.
Patients with foot calluses should contact their doctors before trimming away the thickened skin to avoid infections, states Mayo Clinic. Antibiotics may help treat calluses. Soaking the feet in warm water prior to removing the extra skin may help as well. Moisturizing the skin and using nonprescription pads may also be helpful. Diabetics are likely to contract infections, so they should not use pumice stone to remove the excess skin.