Ways to reduce charlie horse pain include stretching and massaging the muscle, taking the supplement quinine, increasing potassium, calcium and magnesium intake, and drinking more water. If the charlie horse is occurring presently, stretching or massaging the area may provide relief, according to the AARP.
Quinine helps ease the potential of charlie horses at night time, but may be harmful in high doses, says Medicine Daily. Charlie horses have been linked to low levels of the electrolytes calcium, potassium and magnesium, according to the AARP. Low levels of hydration likely lead to the increased potential of charlie horses, so increasing water consumption before bed and before and after a workout may help, according to WebMD.