Running burns roughly 30 percent more calories than walking the same distance, according to Natural Health. If a one-mile walk burns 100 calories, a one-mile run burns 130 calories.
It is a common misconception that running and walking burn the same amount of calories, according to Runner's World. In reality, calories are burned for every liter of oxygen used by the body. Because running requires the use of significantly more oxygen than walking, running the same distance actually burns more calories than walking. Natural Health explains that the difference is also partly due to the fact that running involves a greater shift in balance and thus more physical expenditure for the same distance.