Wagner syndrome is a rare disorder characterized by abnormal tissue and blood vessels in the eye, causing progressive loss of vision, according to Genetics Home Reference. Overall vision loss in those affected ranges from slight impairment to total blindness, depending on hereditary factors and management of the syndrome.
Mutations in the VCAN gene cause Wagner syndrome, as noted by Genetics Home Reference. It is typically an inherited condition and affects approximately 300 people worldwide, primarily in the Netherlands. Problems that affect vision usually start during childhood, although vision loss may not occur immediately. People with Wagner syndrome typically develop cataracts, and over time, some also develop nearsightedness, blurry vision and night blindness.