Individuals who are at high risk of developing sarcoma, specifically soft tissue sarcoma, are people with certain genetic malignant disorders, those who are exposed to particular chemicals and people who undergo prior radiation treatment, which often causes lymphedema, as stated by the American Cancer Society. There are 11,930 new cases and 4,870 fatalities attributed to adult soft tissue sarcoma that have been recorded in the United States in 2015, as reported by the National Cancer Institute of the National Institutes of Health.
Radiation therapy is said to be detrimental to the lymphatic system, where the accumulation of lymph fluids potentially leads to lymphangiosarcoma. People with inherited medical conditions, including Gardner syndrome, neurofibromatosis, Werner syndrome, Li-Fraumeni syndrome, retinoblastoma and Gorlin syndrome, are more prone to develop sarcoma. Exposure to arsenic and vinyl chloride are closely associated with hepatic cancer.