Creatine, licorice, magnesium, peony and zinc are herbs and supplements that are used to prevent or treat muscle cramps, says WebMD. However, there is not enough medical evidence to support user claims, as of 2015.
Creatine is commonly used for increased exercise performance. It is also used to increase muscle mass. There is some evidence that shows creatine is effective at boosting the athletic performance of young and healthy adults during short, high-intensity activity. There is no evidence suggesting that it works for people over the age of 60, says WebMD.
Mayo Clinic suggests staying hydrated and stretching to prevent muscle cramps. Water helps muscles relax and hydrated muscle cells are less irritable. During an activity or exercise, drink water at regular intervals and keep consuming fluids after. Stretch before and after any exercise. Stretching before bed can help relieve leg cramps during the night. Mild exercise before bed can also reduce muscle cramps.
Home remedies for treating muscle cramps are massage and applying ice or heat. Mayo Clinic recommends massaging cramped muscles gently to help them relax. Massaging with ice can help reduce pain. Apply a hot towel or heating pad to sore and tense muscles. Take a hot bath or shower to help relieve tension.