As of 2015, there is no definitive scientific evidence to suggest that vitamin E helps in the treatment of Peyronie's disease. Vitamin E may not be recommended for this condition, notes Mayo Clinic.
Vitamin E is an antioxidant noted for its minimal side effects and affordability, states the Urology Care Foundation. Early research suggests that it corrected the problem experienced by men with Peyronie's disease. However, the results of the majority of these studies were not reliable and conclusive.
The use of vitamin E for Peyronie's disease earned a "D" rating at Mayo Clinic. This indicates the availability of only a fair amount of clinical data to support the claim that vitamin E is safe and effective against Peyronie's disease.