Many patients with toenail fungus have had luck with Vicks VapoRub, according to Mayo Clinic. Patients should apply a small amount of the ointment daily with a cotton swab.
Several over-the-counter anti-fungal nail creams and ointments are also available, states Mayo Clinic. Patients should file off any white markings on the surface of the nails, and then soak the nails in water before drying them and applying the medicated cream or lotion. Trimming and filing thick nails is also beneficial, and is most effective with an overnight application of urea cream and covering the nails with a bandage to soften them.