Silvadene® cream is a topical antimicrobial agent used in conjunction with other medications to prevent and treat wound infections in individuals with second- or third-degree burns, according to WebMD. The active ingredient in Silvadene® cream is silver sulfadiazine, which belongs to the class of drugs known as sulfa antibiotics.
In addition to the prevention and treatment of cutaneous infections in patients with serious burns, doctors prescribe silver sulfadiazine for the prevention and treatment of various skin ulcers, particularly decubitus ulcers and lesions infected with methicillin-resistant Staphylococcus aureus, MRSA, states the National Center for Biotechnology Information. When paired with hyaluronic acid, silver sulfadiazine is also helpful in treating individuals with chronic skin lesions due to diabetes.
Silver sulfadiazine exhibits broad antimicrobial activity, reports Drugs.com. It is bactericidal to a wide spectrum of gram-positive and gram-negative bacteria and stops many bacteria that are resistant to other antimicrobial agents. It is also effective against yeast. The application of this topical medicine inhibits the growth of bacteria that may infect an open wound and hinders the spread of any harmful bacteria to surrounding skin or into the bloodstream, adds WebMD. If bacteria spread to the blood, it can cause a blood infection, which is also known as sepsis.