What Is the Typical Treatment for Mastocytosis?


Quick Answer

Common treatment options for mastocytosis include medicines, such as antihistamines, anticholinergics, proton pump inhibitors and steroids, according to Cleveland Clinic. In more serious cases, the patient may need chemotherapy.

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Antihistamines treat mastocytosis by preventing the effects of the chemical mast cell histamine, as Cleveland Clinic explains. Antihistamines help to relieve itching or other skin conditions, combat ulcers, and reduce skin flushing and low blood pressure before general symptoms become apparent. Additional medicinal options include proton pump inhibitors, which help to relieve ulcer-like symptoms; epinephrine to treat anaphylaxis, more commonly known as shock; steroids to help treat malabsorption, which is the body’s inability to take in nutrients; and cromolyn sodium to help reduce abdominal cramping. For more complicated cases, the patient may require chemotherapy and steroids when mastocytosis has become malignant or cancerous or when a blood disorder is apparent.

Mastocytosis is a medical condition characterized by an overabundance of mast cells in the body, explains Mayo Clinic. Mast cells protect against disease and help in the wound-healing process. Alcohol intake, changes in temperature, and some foods and medications trigger the condition, and it causes numerous symptoms, such as flushing in the face, itching, accelerated heart rate, abdominal cramping and lightheadedness.

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