What Is Triamterene-Hydrochlorothiazide?

Triamterene combined with hydrochlorothiazide is a diuretic used to reduce excess water and salt in the body, according to MedlinePlus. The medication is administered orally in a pill form as a tablet or capsule. Common ailments treated by triamterene and hydrochlorothiazide include high blood pressure and edema.

Triamterene and hydrochlorothiazide have a direct effect on the kidneys by controlling how much water and sodium are reabsorbed by the body, as explained by MedicineNet. The kidneys naturally try to compensate for the loss of sodium by replacing it with potassium, thus decreasing potassium levels in the exchange. Hydrochlorothiazide reduces water retention by increasing urine production, while triamterene works to regulate potassium levels.

Lowering a person's blood pressure with triamterene/hydrochlorothiazide can also help prevent strokes, heart attacks and kidney problems, according to MedicineNet. Triamterene/hydrochlorothiazide, also known by the brand name Dyazide, may interact with other drugs, and this could change the way that it works or even increase the side effects of the drug, according to WebMD. A few drugs that interact with Dyazide are dofetilide, lithium and drugs used to increase potassium levels, such as spironolactone, amiloride and cyclosporine.

Furthermore, some cold and cough products, diet aids and nonsteroidal anti-inflammatory drugs contain ingredients that increase blood pressure, which is the opposite of what triamterene/hydrochlorothiazide is used for. There are many other drugs that interact with triamterene/hydrochlorothiazide, so a physician should be informed about all other drugs or medical problems before prescribing this drug, advises Mayo Clinic.