Treatment for stage IV chronic lymphocytic leukemia, or CLL, often includes watchful waiting, targeted therapies, chemotherapy and low-dose external radiation therapy, according to the National Cancer Institute. Doctors sometimes recommend that patients with CLL participate in clinical trials when other treatments are ineffective.
Oncologists sometimes recommend watchful waiting when CLL causes no symptoms or signs, notes the National Cancer Institute. Targeted therapies, including monoclonal antibody or tyrosine kinase inhibitor therapies, sometimes prove beneficial for stage IV CLL patients, by attacking specific cancer cells and leaving healthy cells intact. Low-dose external radiation targeting the areas affected by cancer, including the lymph nodes and spleen, is another option. Treatment options recommended depend largely on the patient’s health and tolerance of treatments available.