There is evidence that vitamin B-12, in combination with folic acid and other B vitamins, is effective in reducing homocysteine levels, according to Mayo Clinic. Green leafy vegetables, fruits, and fortified grain products contain B vitamins, as stated by WebMD. Supplementation with B vitamins is another option.
Homocysteine is an amino acid present in the blood, and a link exists between high levels of homocysteine and the development of heart disease, as explained by Mayo Clinic. Although increasing consumption of B vitamins lowers homocysteine levels, studies have shown that this does not reduce the risk of heart disease, warns WebMD.