The best treatment for diabetes inspidus is to drink lots of fluids, according to WebMD. This allows the body to replace the fluid lost by constant urination. Replacing fluid is especially important for people who exercise in the heat.
A doctor may also prescribe vasopressin, according to Drugs.com. This is a synthetic, antidiuretic hormone that supports the production of antidiuretic hormone, or ADH, that's normally made in the hypothalamus and stored in the pituitary gland. Vasopressin cuts down on the amount of urine the person is passing and helps the kidneys retain water. It also causes blood vessels to constrict and raises blood pressure. Vasopressin can be taken orally or as a nasal spray.
Diabetes inspidus can be caused by the failure of the kidneys to respond to antidiuretic hormone, according to WebMD. Sometimes, this is caused by the drugs the patient is taking. Stopping the drug under a doctor's supervision can sometimes be enough to remove the symptoms of diabetes insipidus. If medication isn't the problem, the individual can be treated with drugs such as indomethacin.
Indomethacin is a nonsteroidal anti-inflammatory drug, or NSAID, according to Drugs.com. It reduces the levels of those hormones that cause inflammation. Diuretics are another treatment for diabetes insipidus, states WebMD.