The best treatment for valley fever is bed rest and fluids, according to the Mayo Clinic. Most otherwise healthy people who have valley fever never require medical treatment for the illness.
If valley fever symptoms do not improve or become worse with bed rest and fluids, a doctor can prescribe an antifungal medication, according to the Mayo Clinic. If the valley fever symptoms are severe, a doctor may opt to give the antifungal drugs intravenously at first. Because the antifungal drugs effectively control fungus but may not destroy it, relapse is possible. One bout with valley fever is usually enough to develop an immunity to the condition.