The most effective treatment for locally advanced kidney cancer is surgery, according to the Canadian Urological Association Journal. The benefits of medications, such as tyrosine-kinase inhibitors, and radiation are uncertain.
Surgical techniques involve cutting the kidney and sometimes the liver away from surrounding structures and tying off renal veins and arteries, says the Canadian Urological Association Journal. This starves the tumor of blood, which causes it to shrink and allows easier removal. A doctor debulks, or removes as much cancer as possible, in a patient if the cancer has spread to nearby organs, such as the liver or the spleen, though this type of metastasis is rare and indicates a poor prognosis.