A 24-week regimen of sofosbuvir and ribavirin is the recommended treatment for hepatitis C genotype 3, according Hepatitis C Online in 2015. For patients who are able to receive interferon, Hepatitis C Online suggests adding weekly doses of peginterferon alfa-2a or peginterferon alfa-2b to the recommended treatment.
Hepatitis C genotype 3 does not respond to the direct-acting antiviral drugs used for other hepatitis C genotypes, and genotype 3 patients have higher rates of serious liver complications, Hepatitis C Online reports. Direct-acting antiviral drugs were developed for Hepatitis C genotypes 1 and 2 before any were studied for genotype 3 because genotype 3 is relatively rare, accounting for about 10 percent of U.S. Hepatitis C cases, as of 2015.