A combination of drugs is the best treatment for leprosy, according to the World Health Organization. Rifampicin, dapsone and clofazimine are combined in various permutations, depending on the type of leprosy under treatment.
In cases of paucibacillary leprosy, a combination of dapsone and rifampicin is the recommended treatment. In cases of multibacillary leprosy, patients take a combination of dapsoe, rifampicin and clofazimine. In cases involving a single lesion, treatment is often successful after just one combination dose, as stated by the World Health Organization.
In situations in which the type of leprosy is unclear, the three-medicine regimen for multibacillary leprosy is the proper treatment. Paucibacillary leprosy treatment does not work for multibacillary leprosy, but the multibacillary treatment regimen works for both. In an ideal situation, the patient reports to a clinic monthly for administration of the medicine. However, in some parts of the world, that is impractical, in which case a community member or relative is designated to provide the medicine. Following the protocol ordered by the doctor is crucial for maintaining health over the long term. This makes educating the patient an integral part of initiating treatment. Providing this sort of information often motivates patients to take ownership of their own cases, notes the World Health Organization.